Dogs

Polymorphisms in canine immunoglobulin heavy chain gene cluster: a double‐edged sword for diabetes mellitus in the dog

1 month ago   |   By Animal Genetics

Summary
Insulin deficiency diabetes in dogs is an endocrine disease similar to human type 1 diabetes. There are breeds more commonly affected, such as Yorkshire Terrier and Samoyed, suggesting an underlying genetic component. However, the genetic basis for canine diabetes mellitus is not fully established. We conducted both whole‐genome scans for selection signatures and GWASs to compare the genomes of 136 dogs belonging to 29 breeds previously described at low or high risk for developing DM. Candidate variants were tested in dogs with a diagnosis of IDD and controls attending the...
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