Discriminating between allele‐ and genotype‐specific transmission ratio distortion

6 monthes ago   |   By Animal Genetics

Summary
Transmission ratio distortion is defined as the observed deviation from the expected Mendelian inheritance of alleles from heterozygous parents. This phenomenon is attributed to various biological mechanisms acting on germ cells, embryos or fetuses, or even in early postnatal life. Current statistical approaches typically use two independent parametrizations assuming that TRD relies on allele‐ or genotype‐related mechanisms, although they have never been tested and compared. This study compared allele‐ and genotype‐related TRD models on simulated datasets with 1000 genotyped...
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